CDT1 overexpression suppresses DNA replication and triggers DNA damage linked to cancer, finds study

A research group has demonstrated that overexpression of Cdc10-dependent transcript 1 (CDT1), a key regulator of DNA ...

Uncovering the principle by which DNA replication initiation sites are determined in the human genome

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...
EurekAlert!

CDT1 overexpression suppresses DNA replication and induces DNA damage, suggesting a mechanism for cancer development

A research group led by Drs. Shusuke Tada and Takashi Tsuyama at the Department of Molecular Biology, Faculty of ...
News-Medical.Net on MSN

New method reveals how human cells initiate DNA replication

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...
AZoLifeSciences on MSN

Study uncovers principles guiding replication initiation across the human genome

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

New Discovery Exposes the Hidden Weak Spot Cancer Uses to Survive DNA Damage

Scripps Research scientists have discovered how some tumors endure DNA damage, revealing a potential new way to target them. The DNA inside our cells is constantly exposed to damage, and one of the ...
Nature

Replication and replicability

The process of independently repeating earlier studies—by interrogating the same research questions, and employing the same or similar methods and data—is broadly considered the cornerstone of science ...