Following the Structural Genomics Initiative to solve as many unique protein structures as possible; the Protein Data Bank contains several enzymes whose structures have been solved, but for which no ...

While protein design is experiencing a period of rapid development and advancement, there’s one particularly challenging class of proteins that’s giving researchers a hard time: enzymes. Now ...

Breast cancer is a highly heterogeneous disease, with many subtypes showing distinct pathological features and clinical outcomes. Among different subtypes, luminal breast cancer accounts for more than ...

Respiratory infections can be severe, even deadly, in some individuals, but not in others. Scientists have gained new understanding of why this is the case by uncovering an early molecular driver that ...

Lipid recycling in organelles called lysosomes depends on the lipid BMP, which was thought to be resistant to degradation by lysosomal enzymes. It emerges that the enzyme PLA2G15 breaks down BMP, and ...

A research team has successfully engineered a novel PET hydrolase enzyme, PET2-21M, achieving a remarkable improvement in the biodegradation of bottle-grade polyethylene terephthalate (PET) plastics.

New research represents a notable step forward in designing enzymes from scratch. With their approach, the authors designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, ...